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-synuclein, which happens to be a primary part of Lewy bodies, in PARK 1 in 1997 and parkin in PARK 2 in 1998, which is an E3 ubiquitin ligase and triggers endoplasmic reticulum (ER) stress, recommend that dysfunction of the intracellular proteinase programs, like ubiquitin-proteasome process or lysosomal method, which eliminates unwanted toxic pro